2023
Deppmann, C.D. and Zunder, E.R., 2023. The good, the bald, and the hairy: A mechanosensor meets its fate at the target. Developmental Cell, 58(20), pp.2013-2014.
Tang, Q., Godschall, E., Brennan, C. D., Zhang, Q., Abraham-Fan, R. J., Williams, S. P., Güngül, T. B., Onoharigho, R., Buyukaksakal, A., Salinas, R., Sajonia, I. R., Olivieri, J. J., Calhan, O. Y., Deppmann, C. D., Campbell, J. N., Podyma, B., & Güler, A. D. (2023). Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network. Science advances, 9(34), eadh9570. https://doi.org/10.1126/sciadv.adh9570
Mason, A.J., Deppmann, C. and Winckler, B., 2023. Emerging Roles of Neuronal Extracellular Vesicles at the Synapse. The Neuroscientist, p.10738584231160521.
Mason, A.J., Keeler, A.B., Kabir, F., Winckler, B. and Deppmann, C., 2023. Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles. Scientific Reports, 13(1), p.3657.
Kumar, S., Budhathoki, S., Oliveira, C. B., Kahle, A. D., Calhan, O. Y., Lukens, J. R., & Deppmann, C. D. (2023). Role of the caspase-8/RIPK3 axis in Alzheimer's disease pathogenesis and Aβ-induced NLRP3 inflammasome activation. JCI insight, 8(3), e157433. https://doi.org/10.1172/jci.insight.157433
Vradenburgh, S. A., Van Deusen, A. L., Beachum, A. N., Moats, J. M., Hirt, A. K., Deppmann, C. D., Keeler, A. B., & Zunder, E. R. (2023). Sexual dimorphism in the dorsal root ganglia of neonatal mice identified by protein expression profiling with single-cell mass cytometry. Molecular and cellular neurosciences, 126, 103866. Advance online publication. https://doi.org/10.1016/j.mcn.2023.103866
Zimyanin, V. L., Pielka, A. M., Glaß, H., Japtok, J., Großmann, D., Martin, M., Deussen, A., Szewczyk, B., Deppmann, C., Zunder, E., Andersen, P. M., Boeckers, T. M., Sterneckert, J., Redemann, S., Storch, A., & Hermann, A. (2023). Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons. Cells, 12(10), 1352. https://doi.org/10.3390/cells12101352
2022
Keeler AB, Van Deusen AL, Gadani IC, Williams CM, Goggin SM, Hirt AK, Vradenburgh SA, Fread KI, Puleo EA, Jin L, Calhan OY, +Deppmann CD, +Zunder ER. A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry. Nat Neurosci.
Favichia, M., Gibney, T., Kowalewski, K., Pani, A., Deppmann, C. Salt, Fat, Acid, Heat: Modulators of Signal Transduction. eLS.
Van Deusen, A. L., Goggin, S. M., Williams, C. M., Keeler, A. B., Fread, K. I., Cheng, I., Deppmann, C. D., Zunder, E. R. A developmental atlas of the mouse brain by single-cell mass cytometry. bioRxiv.
McDermott, C., Gaona-Gamboa, A., Lee, S. H., Sesco, E., Deppmann, C. The Role of Posttranslational Modification in Cellular Function. eLS (pp. 1-10).
2021
Grannonico, M., Miller, D., Liu, M. N., Norat, P., Deppmann, C. D., Netland, P. A., Zhang, H. F., Liu, X. R. Global and regional damages in retinal ganglion cell axon bundles monitored non-invasively by visible-light optical coherence tomography fibergraphy. Journal of Neuroscience (pp. 10179-10193)
Yong, Y., Hunter-Chang, S., Stepanova, E., Deppmann, C. Axonal spheroids in neurodegeneration. Molecular and Cellular Neuroscience 117, 103679.
Podyma, B., Parekh, K., Güler, A.D., Deppmann, C.D. Metabolic homeostasis via BDNF and its receptors. Trends in Endocrinology & Metabolism (pp. 488-499).
Pathak, A., Clark, S., Bronfman, F. C., Deppmann, C. D., Carter, B. D. Long-distance regressive signaling in neural development and disease. Developmental Biology 10 (2), e382.
2020
Yong, Y., Gamage, K., Cushman, C., Spano, A., & Deppmann, C. D. (in press). Regulation of degenerative spheroids after injury. Scientific Reports
Yong, Y., Hughes, C., & Deppmann, C. (2020). A Microfluidic Culture Platform to Assess Axon Degeneration. In Axon Degeneration (pp. 83-96). Humana, New York, NY.
Podyma B, Johnson DA, Sipe L, Remcho TP, Battin K, Liu Y, Yoon SO, +Deppmann CD, +Güler AD. (2020) The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation. Elife. PMID: 31995032.
Girouard M-P, Simas T, Hua L, Morquette B, Khazaei MR, Unsain N, Johnstone AD, Rambaldi I, Sanz RL, Raddo M-ED, Gamage KK, Yong Y, Willis DE, Verge VMK, Barker PA, Deppmann C, +Fournier AE. (2020) Collapsin response mediator protein 4 (CRMP4) facilitates Wallerian degeneration and axon regeneration following sciatic nerve injury. eNeuro. PMID: In process
Kuhn, K.D., Edamura, K., Bhatia, N., Cheng, I., Clark, S.A., Haynes, C.V., Heffner, D.L., Kabir, F., Velasquez, J., Spano, A.J., +Deppmann, C.D., and +Keeler AB 2020. Molecular dissection of TNFR-TNFα bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning. Molecular and Cellular Neuroscience, p.103467.
Grippo RM, Tang Q, Zhang Q, Chadwick SR, Gao Y, Altherr EB, Sipe L, Purohit AM, Purohit NM, Sunkara MD, Cios KJ, Sidikpramana M, Spano AJ, Campbell JN, Steele AD, Hirsh J, Deppmann CD, Wu M, Scott MM, Güler AD. (2020) Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding. Curr Biol. PMID: 31902720.
2019
Wheeler MA, Deppmann CD, Patel MK, +Güler AD. Reply to: Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells, Assessing the utility of Magneto to control neuronal excitability in the somatosensory cortex and Revaluation of magnetic properties of Magneto. Nat Neurosci. 2019 PMID: 31570860
*Yong, Y., *Gamage, K., Cheng, I., Barford, K., Spano, A., Winckler, B. and +Deppmann, C., (2019). p75NTR and DR6 regulate distinct phases of axon degeneration demarcated by spheroid rupture. Journal of Neuroscience, 39(48), pp.9503-9520. PMID 31902720
2018
Ray, S., Tillo, D., Assad, N., Ufot, A., Deppmann, C., Durell, S.R., Porollo, A. and Vinson, C., 2018. Replacing C189 in the bZIP domain of Zta with S, T, V, or A changes DNA binding specificity to four types of double-stranded DNA. Biochemical and biophysical research communications, 501(4), pp.905-912.
Cheng, I., Jin, L., Rose, L.C. and Deppmann, C.D., 2018. Temporally restricted death and the role of p75 NTR as a survival receptor in the developing sensory nervous system. Developmental neurobiology.
Barford, K., Keeler, A., McMahon, L., McDaniel, K., Yap, C.C., Deppmann, C.D. and Winckler, B., 2018. Transcytosis of TrkA leads to diversification of dendritic signaling endosomes. Scientific reports, 8(1), p.4715.
2017
Sipe, L. M., C. Yang, J. Ephrem, E. Garren, J. Hirsh, and C. D. Deppmann. "Differential sympathetic outflow to adipose depots is required for visceral fat loss in response to calorie restriction." Nutrition & diabetes 7, no. 4 (2017): e260.
Smith, C.J., Wheeler, M.A., Marjoram, L., Bagnat, M., Deppmann, C.D. and Kucenas, S., 2017. TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. PLoS genetics, 13(4), p.e1006712.
Gamage, K.K., Cheng, I., Park, R.E., Karim, M.S., Edamura, K., Hughes, C., Spano, A.J., Erisir, A. and Deppmann, C.D. Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons. Current Biology. Current Biology (2017)
2016
Wheeler MA, Smith CJ, Ottolini M, Barker BS, Purohit AM, Grippo RM, Gaykema RP, Spano AJ, Beenhakker MP, Kucenas S, Patel MK, Deppmann CD, Güler AD. Genetically targeted magnetic control of the nervous system. (2016) Nature Neuroscience
See Also: This article has been covered by 20 independent international news agencies including The Guardian, The Scientist, Daily Mail, Fox News and Arstechnica (as of March 25th, 2016). Nature Reviews will be highlighting it in the upcoming issue. Online attention and activity reported by Altmetric scores this article in the 99th percentile compared to all other articles of the same age and is the 22nd out of roughly 3000 Nature neuroscience articles. For more context see: https://nature.altmetric.com/details/6133441#score
2015
Suo, D., Park, J., Young, S., Makita, T., & Deppmann, C. D. (2015). Coronin-1 and Calcium Signaling Governs Sympathetic Final Target Innervation. The Journal of Neuroscience, 35(9), 3893-3902.
2014
Wheeler, M., Heffner, D., Kim, S., Espy S., Spano, A. Cleland, C., & Deppmann, CD (2014) TNFα/TNFR1 forward and reverse signaling is required for the development and function of primary nociceptors. Neuron 82(3):587-602. Link
See Also: Science Signaling Editor's Choice: Dual Action Pain Modulator. Link
Sokolowski, J. D., Gamage, K. K., Heffron, D. S., LeBlanc, A. C., Deppmann, C. D., & Mandell, J. W. (2014). Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury. Acta neuropathologica communications, 2, 16. Link
Parameswaran, Nevi, Benjamin G. Dewals, Tom C. Giles, Christopher Deppmann, Martin Blythe, Alain Vanderplasschen, Richard D. Emes, and David Haig. "The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits." Virus research (2014). Link
Suo, D., Park, J., Harrington, A. W., Zweifel, L. S., Mihalas, S., & Deppmann, C. D. (2014). Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nature neuroscience, 17(1), 36-45. PMID: 24270184
2012
Vaccari, A., ^Gamage, K.K., #Nachum, S., Condron, B., Deppmann C.D., Acton, S.T., (2012) Image Analysis for Automated Assessment of Axon Degeneration. Asilomar Conf. on Signals, Systems and Computers. Link
Blasier, K.R., Mitchell, D.J., Ross,M.W., Smiley,W.R., ^Suo, D., #Park, J., Pullikuth, A.K., Catling, A.D., Deppmann, C.D., Pfister, K.K. Recruitment of dynein to endosomes for retrograde survival signal transport requires specific phosphorylation of the dynein intermediate chain by a Trk/ERK pathway. J. Neuroscience (2012) 32(44):15495-510 Link
pre-2010
*Sharma N, *Deppmann C.D., *Harrington A.W., St Hillaire C., Chen Z.Y., Lee F.S., Ginty D.D. (2010) Long-Distance Control of Synapse Assembly by Target-Derived NGF. Neuron. 2010 Aug 12;67(3):422-34. Link
See Also:
Newbern, J.M., Li, X., Snider, W.D. (2010) Signaling Endosomes Trigger Synapse Assembly. Neuron. Aug 12;67(3):352-4. Link
Faculty of 1000: evaluations for Sharma et al., Neuron (2010) Link
Wong, Wei. "Synapse Specification Goes Retro." Science Signalling 3.135 (2010): ec248. Link
*Deppmann, C.D., *Mihalas, S., *Sharma, N., Lonze, B.E., Niebur, E, Ginty D.D. (2008) A Model for Neuronal Competition During Development. Science, 320(5874) 369-73. Link
See Also:
Davies, A.M. (2008) Neurotrophins giveth and they taketh away. Nat. Neuro. 11(6):627-8. Link
Li, Y., Fivaz, M. (2008) Feedback-mediated neuronal competition for survival cues regulates innervation of a target tissue. Bioessays. 30(10):929-33 Link
Faculty of 1000 Medicine: evaluations for Deppmann CD et al Science 2008 Apr 18 320 (5874) :369-73 http://www.f1000medicine.com/article/id/1117911/evaluation
Deppmann, C.D., Alvania, R.A., Taparowsky, E.J. (2006) Cross-species Annotation of Basic Leucine Zipper Factor Interactions: Insight Into the Evolution of Closed Interaction Networks. Mol. Biol. Evol. 23(8), 1480-92. Link
Deppmann, C.D., Acharya, A., Rishi, V., Wobbes, B., Smeekens, S., Taparowsky, E.J., Vinson, C. (2004). Dimerization Specificity of All 67 B-ZIP Motifs in Arabidopsis thaliana: A Comparison to Homo sapiens B-ZIP Motifs. Nuc. Acids Res. 32(11), 3435-45. Link
Deppmann, C.D., Thornton T.M., Utama, F.E., Taparowsky, E.J. (2003). Phosphorylation of BATF Regulates DNA binding: a Novel Mechanism for AP-1 (Activator Protein-1) Regulation. Biochem J. 374(Pt 2), 423-31. Link
Johansen L.M., Deppmann, C.D., Erickson K.D., Coffin W.F. 3rd, Thornton T.M., Humphrey S.E., Martin, J.M. Taparowsky, E.J. (2003). BATF is a Cellular Target of the Epstein-Barr Virus Transactivator Protein, EBNA-2. J. Virol. 77, 6029-40. Link
Williams K.L., Zullo, A.J., Kaplan, M.H., Brutkiewicz, R.R., Deppmann, C.D., Vinson C, Taparowsky, E.J. (2003). BATF Transgenic Mice Reveal a Role for AP-1 in NKT Cell Development. J. Immunol. 170, 2417-26. Link
Deppmann, C.D., Taparowsky, E.J. (2003). Reverse-polarity PAGE for examining DNA binding domain phosphorylation. Biotechniques. 34, 56-9.
Book Chapters and Reviews:
2020
Clark, S.A., and +Deppmann, C.D., (2020). Fight or Flight Turns Hair White. (2020) Nature PMID: 31988402
Pathak, A., Clark, S., Bronfman, F.C., Deppmann, C.D. and Carter, B.D., 2020. Long‐distance regressive signaling in neural development and disease. Wiley Interdisciplinary Reviews: Developmental Biology, p.e382.
2019
Cook, SR, Hart WS, Zatorski, JM, Flick M, Deppmann CD. The Signaling Involved with Wound Healing: Recent Advances and Potential Applications (2019) Encyclopedia of Life Sciences.
2018
McGirr, B.*, Tubergen, P*, Hartz, J., Myers, P., Pittman, M., Lazzara, M., Deppmann, C. A Process Controls Approach to Cell Signaling, Encyclopedia of Life Sciences.Invited review (2018) PMCID: NA
McMullen, T.*, Brown, E*, Ausrafuggaman, N., Sahu, A., Guler, A., Deppmann, C.GPCR signal transduction: Evolution by gene duplication, Encyclopedia of Life Sciences.Invited review, (2018) PMCID: NA
2017
Barford K, Keeler A, Deppmann C, Winckler B. TrkA Bumps into Its Future Self. Dev Cell. 2017 Sep 25;42(6):557–558. PMID: 28950095
Barford K, Deppmann C, Winckler B. The neurotrophin receptor signaling endosome: Where trafficking meets signaling. Dev Neurobiol. 2017 Feb 24;77(4):405–418. PMCID: PMC5661883
Yong, Yu, Heckle, Lindsay A, Arena, Kimberly A, Goertz, Jennifer E, Kucenas, Sarah, and Deppmann, Christopher D(Aug 2017) Glia Signalling during Neurological Damage and Disease. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0027501] PMCID: NA
Guessoum, Omar, Tang, Qijun, Agorsor, Israel DK, Ke, Wenfan, Li, Renyu, Danna, Cristian H, and Deppmann, Christopher D(Aug 2017) TLR Signalling: Beyond Immunity. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0027502] PMCID: NA
Keeler AB, Deppmann CD. The evolutionary origins of antagonistic neurotrophin signaling. J Cell Biol. 2017 May 1;216(5):1223–1225. PMCID: PMC5412573
Martorella M, Barford K, Winkler B, Deppmann CD. Emergent Role of Coronin-1a in Neuronal Signaling. Vitam Horm. 2017;104:113–131. PMCID: PMC5667946
2016
Ross, EF Ali, MF, Woo, LA, Chadwick, SR Lee, E. Sangston, RM, Sood, C, Zhang, Q Zhang, X, +Deppmann, CD(2016) Reverse Signaling Encyclopedia of Life Sciences. PMCID: NA
2015
Huckaby A, Dombrovski M, Maher E, Naimi W, Perez M, Skyberg R, Smolko C, Barford K, Winckler B, +Deppmann CD. (November 2015) Signaling from endosomes and exosomes. Encyclopedia of Life Sciences. PMCID: NA
2013
*^Pahl, M, *^Askinazi, O., *^Hamilton, M., ^Cheng, I., ^Kuhn, J., ^Cichewicz, K., +Deppmann, C.D. (2013) Signaling via single-pass transmembrane receptors. Encyclopedia of Life Sciences. Link
+Deppmann, C.D., and +Janes K. (2013) Cytokine-cytokine crosstalk and cell-death decisions. Systems Biology of Apopotosis. Springer publishers. Systems Biology of Apoptosis : 163-180. Link
2012
*^Kodis, E., *^Smindek, R., *^Kefauver, J., *Heffner, D., ^Aschenbach, K., Brennan, E., #Chan, K., ^Gamage, K.K., #Lambeth, P., Lawler, J., ^Sikora, A., #Vercroysse, N., +Deppmann C.D. First Messengers. Encyclopedia of Life Sciences. (2012) Link
2006
Deppmann, C.D., Ginty D.D. (2006) Retrograde Control of Neural Circuit Formation. Cell 127(7) 1306-7. Link
+ Corresponding Author
*equal contribution
#UVA Undergrad Student
^UVA Grad student